Article
Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo.
PloS one - 19 Nov 2010
Sartori da Silva Maria A, Tee Jin-Ming, Paridaen Judith, Brouwers Anke, Runtuwene Vincent, Zivkovic Danica, Diks Sander H, Guardavaccaro Daniele, Peppelenbosch Maikel P
Abstract excerpt
ECS (Elongin BC-Cul2/Cul5-SOCS-box protein) ubiquitin ligases recruit substrates to E2 ubiquitin-conjugating enzymes through a SOCS-box protein substrate receptor, an Elongin BC adaptor and a cullin (Cul2 or Cul5) scaffold which interacts with the RING protein. In vitro studies have shown that the conserved amino acid sequence of the cullin box in SOCS-box proteins is required for complex formation and function....
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