Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.

Nature - 18 Sept 2003

Xu Lai, Wei Yue, Reboul Jerome, Vaglio Philippe, Shin Tae-Ho, Vidal Marc, Elledge Stephen J, Harper J Wade

Abstract excerpt

Programmed destruction of regulatory proteins through the ubiquitin-proteasome system is a widely used mechanism for controlling signalling pathways. Cullins are proteins that function as scaffolds for modular ubiquitin ligases typified by the SCF (Skp1-Cul1-F-box) complex. The substrate selectivity of these E3 ligases is dictated by a specificity module that binds cullins. In the SCF complex, this module is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Amino Acid Motifs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans

Share to Caenorhabditis elegans Proteins

Share to Cullin Proteins

Share to Peptide Synthases

Share to SKP Cullin F-Box Protein Ligases

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 13679922
DOI: 10.1038/nature01985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.PMID 13679922Read ↗

The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.Semantic proximity Read ↗

Cullin‐based ubiquitin ligases: Cul3–BTB complexes join the familySemantic proximity Read ↗

F-box proteins: more than baits for the SCF?Semantic proximity Read ↗

The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in <i>Arabidopsis</i>Semantic proximity Read ↗

Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis.Semantic proximity Read ↗

A novel missense variant in CUL3 shows altered binding ability to BTB-adaptor proteins leading to diverse phenotypes of CUL3-related disorders.Semantic proximity Read ↗

Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4BSemantic proximity Read ↗

Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligasesSemantic proximity Read ↗

KBTBD13 interacts with Cullin 3 to form a functional ubiquitin ligase.Semantic proximity Read ↗

Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.Semantic proximity Read ↗

CRL4s: the CUL4-RING E3 ubiquitin ligases.Semantic proximity Read ↗

Identification of Elongin C and Skp1 sequences that determine Cullin selection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.