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Article

UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 7 Jul 2016

Safdar Komal, Gu Anniya, Xu Xia, Au Vinci, Taylor Jon, Flibotte Stephane, Moerman Donald G, Maine Eleanor M

Abstract excerpt

Notch-type signaling mediates cell-cell interactions important for animal development. In humans, reduced or inappropriate Notch signaling activity is associated with various developmental defects and disease states, including cancers. Caenorhabditis elegans expresses two Notch-type receptors, GLP-1 and LIN-12. GLP-1 mediates several cell-signaling events in the embryo and promotes germline proliferation in the...

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Identifiers

PMID: 27185398
DOI: 10.1534/g3.116.027805
PMCID: PMC4938665

Genes

UBR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans.PMID 27185398Read ↗

SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans.Semantic proximity Read ↗

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UBR7 functions with UBR5 in the Notch signaling pathway and is involved in a neurodevelopmental syndrome with epilepsy, ptosis, and hypothyroidism.Semantic proximity Read ↗

Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.Semantic proximity Read ↗

The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis.Semantic proximity Read ↗

The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein.Semantic proximity Read ↗

The Bro1-domain protein, EGO-2, promotes Notch signaling in Caenorhabditis elegans.Semantic proximity Read ↗

Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans.Semantic proximity Read ↗

lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans.Semantic proximity Read ↗

HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype That Affects Adult Germline Function in Caenorhabditis elegans.Semantic proximity Read ↗

Enhancers of glp-1, a gene required for cell-signaling in Caenorhabditis elegans, define a set of genes required for germline development.Semantic proximity Read ↗

Two homologous regulatory genes, lin-12 and glp-1, have overlapping functions.Semantic proximity Read ↗

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