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Article

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta.

Development (Cambridge, England) - 1 May 2005

Lai Eric C, Roegiers Fabrice, Qin Xiaoli, Jan Yuh Nung, Rubin Gerald M

Abstract excerpt

The receptor Notch and its ligands of the Delta/Serrate/LAG2 (DSL) family are the central components in the Notch pathway, a fundamental cell signaling system that regulates pattern formation during animal development. Delta is directly ubiquitinated by Drosophila and Xenopus Neuralized, and by zebrafish Mind bomb, two unrelated RING-type E3 ubiquitin ligases with common abilities to promote Delta endocytosis and...

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Source

Identifiers

PMID: 15829515
DOI: 10.1242/dev.01825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta.PMID 15829515Read ↗

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila.Semantic proximity Read ↗

Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila.Semantic proximity Read ↗

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.Semantic proximity Read ↗

Identification of the Mind Bomb1 Interaction Domain in Zebrafish DeltaD.Semantic proximity Read ↗

Mind bomb-2 is an E3 ligase for Notch ligand.Semantic proximity Read ↗

An obligatory role of mind bomb-1 in notch signaling of mammalian development.Semantic proximity Read ↗

Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.Semantic proximity Read ↗

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.Semantic proximity Read ↗

Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila.Semantic proximity Read ↗

Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.Semantic proximity Read ↗

Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta.Semantic proximity Read ↗

Drosophila Ndfip is a novel regulator of Notch signaling.Semantic proximity Read ↗

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