Article
The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.
Nature cell biology - 1 Jul 2005
Dentice Monica, Bandyopadhyay Amitabha, Gereben Balázs, Callebaut Isabelle, Christoffolete Marcelo A, Kim Brian W, Nissim Sahar, Mornon Jean-Paul, Zavacki Ann Marie, Zeöld Anikó, Capelo Luciane P, Curcio-Morelli Cyntia, Ribeiro Rogério, Harney John W, Tabin Clifford J, Bianco Antonio C
Abstract excerpt
WSB-1 is a SOCS-box-containing WD-40 protein of unknown function that is induced by Hedgehog signalling in embryonic structures during chicken development. Here we show that WSB-1 is part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2). The WD-40 propeller of WSB-1 recognizes an 18-amino-acid loop in D2 that confers metabolic instability, whereas the SOCS-box...
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