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Regulatory BC1 RNA and the Fragile X Mental Retardation Protein: Convergent Functionality in Brain

23 Nov 2010

Abstract excerpt

BACKGROUND: BC RNAs and the fragile X mental retardation protein (FMRP) are translational repressors that have been implicated in the control of local protein synthesis at the synapse. Work with BC1 and Fmr1 animal models has revealed that phenotypical consequences resulting from the absence of either BC1 RNA or FMRP are remarkably similar. To establish functional interactions between BC1 RNA and FMRP is...

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PMID: 21124905
DOI: 10.1371/journal.pone.0015509

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