Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fragile X mental retardation protein regulates new neuron differentiation in the adult olfactory bulb.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Feb 2011

Scotto-Lomassese Sophie, Nissant Antoine, Mota Tatiana, Néant-Féry Marie, Oostra Ben A, Greer Charles A, Lledo Pierre-Marie, Trembleau Alain, Caillé Isabelle

Abstract excerpt

The fragile X mental retardation protein (FMRP) is an RNA-binding protein essential for multiple aspects of neuronal mRNA metabolism. Its absence leads to the fragile X syndrome, the most prevalent genetic form of mental retardation. The anatomical landmark of the disease, also present in the Fmr1 knock-out (KO) mice, is the hyperabundance of immature-looking lengthened dendritic spines. We used the well known...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendrites
Share to Dendritic Spines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Excitatory Postsynaptic Potentials

Share to Microscopy, Electron, Transmission

Share to Neurogenesis

Share to Olfactory Bulb

Share to Patch-Clamp Techniques

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 21307257
DOI: 10.1523/JNEUROSCI.5514-10.2011
PMCID: PMC3682409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fragile X mental retardation protein regulates new neuron differentiation in the adult olfactory bulb.PMID 21307257Read ↗

Molecular and cellular aspects of mental retardation in the Fragile X syndrome: from gene mutation/s to spine dysmorphogenesis.Semantic proximity Read ↗

The FXG: A Presynaptic Fragile X Granule Expressed in a Subset of Developing Brain CircuitsSemantic proximity Read ↗

Synaptic synthesis of the fragile X protein: Possible involvement in synapse maturation and eliminationSemantic proximity Read ↗

Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure.Semantic proximity Read ↗

Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation.Semantic proximity Read ↗

Altered synaptic plasticity in a mouse model of fragile X mental retardation.Semantic proximity Read ↗

Correlates across the structural, functional, and molecular phenotypes of fragile X syndrome.Semantic proximity Read ↗

Olfactory deficits in Fragile X syndromeSemantic proximity Read ↗

Proteomics, ultrastructure, and physiology of hippocampal synapses in a fragile X syndrome mouse model reveal presynaptic phenotype.Semantic proximity Read ↗

Analysis of FMR1 deletion in a subpopulation of post-mitotic neurons in mouse cortex and hippocampus.Semantic proximity Read ↗

Impaired dendritic spine development in a zebrafish model of Fragile XSemantic proximity Read ↗

Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.