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Article

CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia.

PLoS genetics - 24 Nov 2010

Lee Dong-Hoon, Singh Purnima, Tsai Shirley Y, Oates Nathan, Spalla Alexander, Spalla Claudio, Brown Lucy, Rivas Guillermo, Larson Garrett, Rauch Tibor A, Pfeifer Gerd P, Szabó Piroska E

Abstract excerpt

Genomic imprints-parental allele-specific DNA methylation marks at the differentially methylated regions (DMRs) of imprinted genes-are erased and reestablished in germ cells according to the individual's sex. Imprint establishment at paternally methylated germ line DMRs occurs in fetal male germ cells. In prospermatogonia, the two unmethylated alleles exhibit different rates of de novo methylation at the H19/Igf2...

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Identifiers

PMID: 21124827
DOI: 10.1371/journal.pgen.1001224
PMCID: PMC2991272

Genes

CTCF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia.PMID 21124827Read ↗

Establishment of paternal methylation imprint at the H19/Igf2 imprinting control region.Semantic proximity Read ↗

More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domainSemantic proximity Read ↗

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Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cellsSemantic proximity Read ↗

Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis.Semantic proximity Read ↗

Allele-specific expression of imprinted genes in mouse migratory primordial germ cells.Semantic proximity Read ↗

Developmental alterations in DNA methylation during gametogenesis from primordial germ cells to spermSemantic proximity Read ↗

CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region.Semantic proximity Read ↗

CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Allele-specific H3K79 Di- versus trimethylation distinguishes opposite parental alleles at imprinted regions.Semantic proximity Read ↗

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