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Sex-Specific Dynamics of Global Chromatin Changes in Fetal Mouse Germ Cells

19 Aug 2011

Abstract excerpt

Mammalian germ cells undergo global reprogramming of DNA methylation during their development. Global DNA demethylation occurs around the time when the primordial germ cells colonize the embryonic gonads and this coincides with dynamic changes in chromatin composition. Global de novo DNA methylation takes place with remarkably different dynamics between the two sexes, prospermatogonia attaining methylation during...

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PMID: 21886830
DOI: 10.1371/journal.pone.0023848

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