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Article

Establishment of paternal methylation imprint at the H19/Igf2 imprinting control region.

Science advances - 8 Sept 2023

Liao Ji, Song Sangmin, Gusscott Samuel, Fu Zhen, VanderKolk Ivan, Busscher Brianna M, Lau Kin H, Brind'Amour Julie, Szabó Piroska E

Abstract excerpt

The insulator model explains the workings of the H19 and Igf2 imprinted domain in the soma, where insulation of the Igf2 promoter from its enhancers occurs by CTCF in the maternally inherited unmethylated chromosome but not the paternally inherited methylated allele. The molecular mechanism that targets paternal methylation imprint establishment to the imprinting control region (ICR) in the male germline is...

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Identifiers

PMID: 37672574
DOI: 10.1126/sciadv.adi2050
PMCID: PMC10482337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Establishment of paternal methylation imprint at the H19/Igf2 imprinting control region.PMID 37672574Read ↗

More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domainSemantic proximity Read ↗

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Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Semantic proximity Read ↗

CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Genomic imprinting recapitulated in the human β-globin locusSemantic proximity Read ↗

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Biallelic expression of imprinted genes in the mouse germ line: implications for erasure, establishment, and mechanisms of genomic imprinting.Semantic proximity Read ↗

Genomic imprinting in germ cells: imprints are under controlSemantic proximity Read ↗

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Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesisSemantic proximity Read ↗

<i>H19</i> Imprinting Control Region Methylation Requires an Imprinted Environment Only in the Male Germ LineSemantic proximity Read ↗

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