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Article

More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domain

1 Jan 2012

Abstract excerpt

CTCF (CCCTC-binding factor)-mediated insulation at the H19-Insulin-like growth factor 2 (Igf2) imprinted domain is a classic example for imprinted gene regulation. DNA methylation difference in the imprinting control region (ICR) is inherited from the gametes and subsequently determines parental allele-specific enhancer blocking and imprinted expression in the soma. Recent genetic studies showed that proper...

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PMID: 23087708
DOI: 10.3389/fgene.2012.00214

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More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domainPMID 23087708Read ↗

Establishment of paternal methylation imprint at the H19/Igf2 imprinting control region.Semantic proximity Read ↗

Epigenetic regulation of Igf2/H19 imprinting at CTCF insulator binding sites.Semantic proximity Read ↗

Role of CTCF binding sites in the Igf2/H19 imprinting control region.Semantic proximity Read ↗

CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region.Semantic proximity Read ↗

Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Semantic proximity Read ↗

CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia.Semantic proximity Read ↗

CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Cohesin mediates transcriptional insulation by CCCTC-binding factor.Semantic proximity Read ↗

The Role of CCCTC-Binding Factor (CTCF) in Genomic Imprinting, Development, and Reproduction1Semantic proximity Read ↗

CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop.Semantic proximity Read ↗

The molecular function and clinical phenotype of partial deletions of the IGF2/H19 imprinting control region depends on the spatial arrangement of the remaining CTCF-binding sites.Semantic proximity Read ↗

Epigenetic regulation of the <i>Igf2/H19</i> gene clusterSemantic proximity Read ↗

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