Article
Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990
Kitayama H, Matsuzaki T, Ikawa Y, Noda M
Abstract excerpt
Kirsten-ras-revertant 1 (Krev-1) cDNA encodes a ras-related protein and exhibits an activity of inducing flat revertants at certain frequencies (2-5% of total transfectants) when introduced into a v-K-ras-transformed mouse NIH 3T3 cell line, DT. Toward understanding the mechanism of action of Kre...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Transformation, Neoplastic
- DNA Mutational Analysis
- GTP-Binding Proteins
- Molecular Sequence Data
- Mutation
- Neoplasms, Experimental
- Oligonucleotides
- Oncogene Protein p21(ras)
- Oncogenes
- Structure-Activity Relationship
- Suppression, Genetic
- Transfection
- rap GTP-Binding Proteins