Article
Identification of small clusters of divergent amino acids that mediate the opposing effects of ras and Krev-1.
Science (New York, N.Y.) - 13 Jul 1990
Zhang K, Noda M, Vass W C, Papageorge A G, Lowy D R
Abstract excerpt
Krev-1 is an anti-oncogene that was originally identified by its ability to induce morphologic reversion of ras-transformed cells that continue to express the ras gene. The Krev-1-encoded protein is structurally related to Ras proteins. The biological activities of a series of ras-Krev-1 chimeras were studied to test the hypothesis that Krev-1 may directly interfere with a ras function. The ras-specific and...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- Cell Transformation, Neoplastic
- Chimera
- GTP-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Harvey murine sarcoma virus
- Molecular Sequence Data