Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The beta-cell in human type 2 diabetes.

Advances in experimental medicine and biology - 1 Jan 2010

Marchetti Piero, Lupi Roberto, Del Guerra Silvia, Bugliani Marco, Marselli Lorella, Boggi Ugo

Abstract excerpt

beta-cell dysfunction is central to the onset and progression of type 2 diabetes. Reduced islet number and/or diminished beta-cell mass/volume in the pancreas of type 2 diabetic subjects have been reported by many authors, mainly due to increased apoptosis not compensated for by adequate regeneration. In addition, ultrastructural analysis has shown reduced insulin granules and morphological changes in several...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to Disease Progression
Share to Inflammation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin

Share to Insulin-Secreting Cells

Share to Islets of Langerhans

Share to Mitochondria

Share to Regeneration

Source

Identifiers

PMID: 20217512
DOI: 10.1007/978-90-481-3271-3_22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The beta-cell in human type 2 diabetes.PMID 20217512Read ↗

Mitochondrial dysfunction in pancreatic beta-cells in Type 2 diabetes.Semantic proximity Read ↗

Inside the β Cell: Molecular Stress Response Pathways in Diabetes PathogenesisSemantic proximity Read ↗

Genetic and biochemical pathways of β‐cell failure in type 2 diabetesSemantic proximity Read ↗

The role of beta-cell dysfunction in early type 1 diabetesSemantic proximity Read ↗

Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes managementSemantic proximity Read ↗

The pancreatic β-cell in ageing: Implications in age-related diabetesSemantic proximity Read ↗

Pancreatic β-Cells and Type 2 Diabetes DevelopmentSemantic proximity Read ↗

Pathophysiology of type 2 diabetes: targeting islet cell dysfunction.Semantic proximity Read ↗

Pancreatic β-cell failure, clinical implications, and therapeutic strategies in type 2 diabetesSemantic proximity Read ↗

Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies.Semantic proximity Read ↗

Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implicationsSemantic proximity Read ↗

Mitochondrial dysfunction and pancreatic islet β‑cell failure (Review)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.