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Article

Mechanisms of leukemogenesis by MLL fusion proteins

1 Dec 2010

Abstract excerpt

Infant acute leukaemia is characterised by specific genetic rearrangements and a rapid onset of disease shortly after birth. The vast majority of these cases bear rearranged MLL alleles. However, many facets of MLL-rearranged leukaemia are largely unknown. Basically, there exists a fundamental and evolutionary conserved relationship between the family of MLL/Trithorax proteins and the regulation of HOX gene...

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PMID: 21118195
DOI: 10.1111/j.1365-2141.2010.08459.x

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