Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromatin modifying activity of leukaemia associated fusion proteins

4 Apr 2005

Abstract excerpt

The leukaemias, which are divided into chronic and acute forms, are malignant diseases of haematopoietic cells in which the proper balance between proliferation, differentiation and apoptosis is no longer operative. Genes, such as those of mixed-lineage leukaemia, AML1 and retinoic acid receptor alpha, have been found to be aberrantly fused to different partners, which often encode transcription factors or other...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15809276
DOI: 10.1093/hmg/ddi109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromatin modifying activity of leukaemia associated fusion proteinsPMID 15809276Read ↗

Emerging roles for chromatin remodeling in cancer biology.Semantic proximity Read ↗

Epigenetic changes: a common theme in acute myelogenous leukemogenesisSemantic proximity Read ↗

Chromatin modifiers and the promise of epigenetic therapy in acute leukemia.Semantic proximity Read ↗

Molecular and Epigenetic Mechanisms of MLL in Human LeukemogenesisSemantic proximity Read ↗

In focus: MLL-rearranged leukemia.Semantic proximity Read ↗

Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair.Semantic proximity Read ↗

Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological InterventionsSemantic proximity Read ↗

Key roles of histone methyltransferase and demethylase in leukemogenesis.Semantic proximity Read ↗

Clinical and molecular consequences of fusion genes in myeloid malignanciesSemantic proximity Read ↗

The molecular biology of mixed lineage leukemiaSemantic proximity Read ↗

Mechanisms of leukemogenesis by MLL fusion proteinsSemantic proximity Read ↗

Mixed lineage leukemia: roles in human malignancies and potential therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.