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Article

Chemical tuning reveals a cation-π gating bridge between the voltage-sensor and pore domains in the Kv7.1 potassium channel.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jan 2026

Schene Miranda E, Ahern Christopher A

Abstract excerpt

Kv7.1 is a cardiac voltage-gated potassium channel that underlies the delayed rectifier current (IKS) in the heart. The slow response to membrane depolarization is a hallmark feature of this channel's physiology, yet the mechanistic basis of how voltage promotes the open potassium conducting state is unknown. We focused on previously identified aromatic residues which might couple the pore and voltage-sensing...

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Identifiers

PMID: 41543902
DOI: 10.1073/pnas.2517495123
PMCID: PMC12818427

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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