Article
Distinctive effects of CCR5, CCR2, and SDF1 genetic polymorphisms in AIDS progression.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 Dec 1998
Hendel H, Hénon N, Lebuanec H, Lachgar A, Poncelet H, Caillat-Zucman S, Winkler C A, Smith M W, Kenefic L, O'Brien S, Lu W, Andrieu J M, Zagury D, Schächter F, Rappaport J, Zagury J F
Abstract excerpt
The Genetics of Resistance to Infection by HIV-1 (GRIV) cohort represents 200 nonprogressor/slow-progressor (Slowprog) and 90 fast-progressor (Fastprog) HIV-1-infected patients. Using this unique assembly, we performed genetic studies on three recently discovered polymorphisms of CCR5, CCR2, and SDF1, which have been shown to slow the rate of disease progression. The increased prevalence of mutant alleles among...
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