Article
RICH2 is implicated in viraemic control of HIV-1 in black South African individuals.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2017
Paximadis Maria, Ngqobe Refilwe N, Chaisson Richard E, Martinson Neil A, Tiemessen Caroline T
Abstract excerpt
An intronic single nucleotide polymorphism (SNP) in RICH2 (rs2072255; 255i), in complete linkage disequilibrium (LD) with an exonic SNP (rs2072254; 254e), has been identified in a genome wide association study to be associated with progression to AIDS in Caucasian individuals. RICH2 links tetherin to the cortical actin network and the RICH2/tetherin interaction has been shown to be important for the downstream...
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