Article
A simple and fast two-locus quality control test to detect false positives due to batch effects in genome-wide association studies.
Genetic epidemiology - 1 Dec 2010
Lee Sang Hong, Nyholt Dale R, Macgregor Stuart, Henders Anjali K, Zondervan Krina T, Montgomery Grant W, Visscher Peter M
Abstract excerpt
The impact of erroneous genotypes having passed standard quality control (QC) can be severe in genome-wide association studies, genotype imputation, and estimation of heritability and prediction of genetic risk based on single nucleotide polymorphisms (SNP). To detect such genotyping errors, a simple two-locus QC method, based on the difference in test statistic of association between single SNPs and pairs of...
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