Article
Quality control for genome-wide association studies.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Gondro Cedric, Lee Seung Hwan, Lee Hak Kyo, Porto-Neto Laercio R
Abstract excerpt
This chapter overviews the quality control (QC) issues for SNP-based genotyping methods used in genome-wide association studies. The main metrics for evaluating the quality of the genotypes are discussed followed by a worked out example of QC pipeline starting with raw data and finishing with a fully filtered dataset ready for downstream analysis. The emphasis is on automation of data storage, filtering, and...
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