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Article

Spoiling the whole bunch: quality control aimed at preserving the integrity of high-throughput genotyping.

American journal of human genetics - 9 Jul 2010

Pluzhnikov Anna, Below Jennifer E, Konkashbaev Anuar, Tikhomirov Anna, Kistner-Griffin Emily, Roe Cheryl A, Nicolae Dan L, Cox Nancy J

Abstract excerpt

False-positive or false-negative results attributable to undetected genotyping errors and confounding factors present a constant challenge for genome-wide association studies (GWAS) given the low signals associated with complex phenotypes and the noise associated with high-throughput genotyping. In the context of the genetics of kidneys in diabetes (GoKinD) study, we identify a source of error in genotype calling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20598280
DOI: 10.1016/j.ajhg.2010.06.005
PMCID: PMC2896766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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