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Article

Identifying and mitigating batch effects in whole genome sequencing data.

BMC bioinformatics - 24 Jul 2017

Tom Jennifer A, Reeder Jens, Forrest William F, Graham Robert R, Hunkapiller Julie, Behrens Timothy W, Bhangale Tushar R

Abstract excerpt

BACKGROUND: Large sample sets of whole genome sequencing with deep coverage are being generated, however assembling datasets from different sources inevitably introduces batch effects. These batch effects are not well understood and can be due to changes in the sequencing protocol or bioinformatics tools used to process the data. No systematic algorithms or heuristics exist to detect and filter batch effects or...

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Identifiers

PMID: 28738841
DOI: 10.1186/s12859-017-1756-z
PMCID: PMC5525370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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