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Article

Approximate and exact tests of Hardy-Weinberg equilibrium using uncertain genotypes.

Genetic epidemiology - 1 Nov 2011

Shriner Daniel

Abstract excerpt

Testing for Hardy-Weinberg equilibrium (HWE) is commonly used as a quality control filter in genome-wide scans for markers with experimentally determined genotypes. In contrast, for markers with imputed genotypes, there are post-imputation metrics of quality that can be used as screens but there are no formal tests of deviation from HWE. Similarly, there are no formal tests of deviation from HWE for probabilistic...

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PMID: 21922537
DOI: 10.1002/gepi.20612
PMCID: PMC4141651

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