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Article

A quality control algorithm for filtering SNPs in genome-wide association studies.

Bioinformatics (Oxford, England) - 15 Jul 2010

Pongpanich Monnat, Sullivan Patrick F, Tzeng Jung-Ying

Abstract excerpt

MOTIVATION: The quality control (QC) filtering of single nucleotide polymorphisms (SNPs) is an important step in genome-wide association studies to minimize potential false findings. SNP QC commonly uses expert-guided filters based on QC variables [e.g. Hardy-Weinberg equilibrium, missing proportion (MSP) and minor allele frequency (MAF)] to remove SNPs with insufficient genotyping quality. The rationale of the...

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PMID: 20501555
DOI: 10.1093/bioinformatics/btq272
PMCID: PMC2894516

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MAF

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