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Article

Direct detection of null alleles in SNP genotyping data.

Human molecular genetics - 15 Jun 2006

Carlson Christopher S, Smith Joshua D, Stanaway Ian B, Rieder Mark J, Nickerson Deborah A

Abstract excerpt

Pinpointing genetic associations in the human genome relies heavily on the accuracy of the underlying genotype data. Null alleles can generate significant inaccuracies in genotype data and can negatively affect the statistical power of a study. Existing quality control (QC) tests, including tests of Hardy-Weinberg equilibrium, are not sensitive enough to detect the presence of even moderately frequent null...

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PMID: 16644863
DOI: 10.1093/hmg/ddl115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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