Article
The effect of genome-wide association scan quality control on imputation outcome for common variants.
European journal of human genetics : EJHG - 1 May 2011
Southam Lorraine, Panoutsopoulou Kalliope, Rayner N William, Chapman Kay, Durrant Caroline, Ferreira Teresa, Arden Nigel, Carr Andrew, Deloukas Panos, Doherty Michael, Loughlin John, McCaskie Andrew, Ollier William E R, Ralston Stuart, Spector Timothy D, Valdes Ana M, Wallis Gillian A, Wilkinson J Mark, Marchini Jonathan, Zeggini Eleftheria
Abstract excerpt
Imputation is an extremely valuable tool in conducting and synthesising genome-wide association studies (GWASs). Directly typed SNP quality control (QC) is thought to affect imputation quality. It is, therefore, common practise to use quality-controlled (QCed) data as an input for imputing genoty...
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