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Article

Structural, mechanistic and clinical aspects of MRP1.

Biochimica et biophysica acta - 6 Dec 1999

Hipfner D R, Deeley R G, Cole S P

Abstract excerpt

The cDNA encoding ATP-binding cassette (ABC) multidrug resistance protein MRP1 was originally cloned from a drug-selected lung cancer cell line resistant to multiple natural product chemotherapeutic agents. MRP1 is the founder of a branch of the ABC superfamily whose members (from species as diverse as plants and yeast to mammals) share several distinguishing structural features that may contribute to functional...

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Identifiers

PMID: 10581367
DOI: 10.1016/s0005-2736(99)00168-6

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