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Article

Epidemiological, clinical and molecular characterization of Lynch‐like syndrome: A population‐based study

21 Dec 2018

Abstract excerpt

Colorectal carcinomas that are mismatch repair (MMR)-deficient in the absence of MLH1 promoter methylation or germline mutations represent Lynch-like syndrome (LLS). Double somatic events inactivating MMR genes are involved in the etiology of LLS tumors. Our purpose was to define the clinical and broader molecular hallmarks of LLS tumors and the population incidence of LLS, which remain poorly characterized. We...

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PMID: 30575961
DOI: 10.1002/ijc.32085

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