Article
A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer.
Cancer research - 1 Dec 2010
Ustach Carolyn V, Huang Wei, Conley-LaComb M Katie, Lin Chen-Yong, Che Mingxin, Abrams Judith, Kim Hyeong-Reh Choi
Abstract excerpt
Increasing evidence indicates the significance of platelet-derived growth factor receptor-β (β-PDGFR) signaling in prostate cancer (PCa). Accordingly, preclinical studies suggest the potential of β-PDGFR as a therapeutic target in metastatic PCa. However, a ligand responsible for β-PDGFR activati...
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