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Article

A novel function for platelet-derived growth factor D: induction of osteoclastic differentiation for intraosseous tumor growth.

Oncogene - 18 Oct 2012

Huang W, Fridman Y, Bonfil R D, Ustach C V, Conley-LaComb M K, Wiesner C, Saliganan A, Cher M L, Kim H-R C

Abstract excerpt

Although increasing evidence suggests a critical role for platelet-derived growth factor (PDGF) receptor β (β-PDGFR) signaling in prostate cancer (PCa) progression, the precise roles of β-PDGFR and PDGF isoform-specific cell signaling have not been delineated. Recently, we identified the PDGF-D isoform as a ligand for β-PDGFR in PCa and showed that PDGF-D is activated by serine protease-mediated proteolytic...

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Identifiers

PMID: 22158043
DOI: 10.1038/onc.2011.573
PMCID: PMC3482867

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