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Strong expression association between matriptase and its substrate prostasin in breast cancer

15 Jun 2011

Abstract excerpt

Breast cancer tumorigenesis is accompanied by increased levels of extracellular proteases that are capable of remodeling the extracellular matrix as well as cleaving and activating growth factors and signaling receptors that are critically involved in neoplastic progression. Multiple studies implicate the membrane anchored serine protease matriptase (also known as MT-SP1 and epithin) in breast cancer. The...

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PMID: 21678412
DOI: 10.1002/jcp.22877

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