β-catenin activation is associated with specific clinical and pathologic characteristics and a poor outcome in adrenocortical carcinoma.

doi:10.1158/1078-0432.CCR-10-2006

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Article

β-catenin activation is associated with specific clinical and pathologic characteristics and a poor outcome in adrenocortical carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2011

Gaujoux Sébastien, Grabar Sophie, Fassnacht Martin, Ragazzon Bruno, Launay Pierre, Libé Rossella, Chokri Ilham, Audebourg Anne, Royer Benedict, Sbiera Silviu, Vacher-Lavenu Marie-Cécile, Dousset Bertrand, Bertagna Xavier, Allolio Bruno, Bertherat Jérôme, Tissier Frédérique

Abstract excerpt

PURPOSE: Activation of the Wnt/β-catenin signaling pathway is frequent in adrenocortical carcinoma (ACC) and might be associated with a more aggressive phenotype. The objective of this study was to assess the prognostic value of β-catenin immunohistochemistry and CTNNB1 (β-catenin gene)/APC (adenomatous polyposis coli gene) mutations in patients with resected primary ACC. EXPERIMENTAL DESIGN: In 79 patients with...

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Identifiers

PMID: 21088256
DOI: 10.1158/1078-0432.CCR-10-2006

Genes

APC
CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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