Article
Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers.
Cancer research - 1 Nov 2010
Ragazzon Bruno, Libé Rossella, Gaujoux Sébastien, Assié Guillaume, Fratticci Amato, Launay Pierre, Clauser Eric, Bertagna Xavier, Tissier Frédérique, de Reyniès Aurélien, Bertherat Jérôme
Abstract excerpt
Adrenocortical carcinoma (ACC) is a rare disease with an overall poor but heterogeneous prognosis. This heterogeneity could reflect different mechanisms of tumor development. Gene expression profiling by transcriptome analysis led to ACC being divided into two groups of tumors with very different outcomes. Somatic inactivating mutations of the tumor suppressor gene TP53 and activating mutations of the...
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