Article
Sarcomatoid adrenocortical carcinoma: a comprehensive pathological, immunohistochemical, and targeted next-generation sequencing analysis.
Human pathology - 1 Dec 2016
Papathomas Thomas G, Duregon Eleonora, Korpershoek Esther, Restuccia David F, van Marion Ronald, Cappellesso Rocco, Sturm Nathalie, Rossi Giulio, Coli Antonella, Zucchini Nicola, Stoop Hans, Oosterhuis Wolter, Ventura Laura, Volante Marco, Fassina Ambrogio, Dinjens Winand N M, Papotti Mauro, de Krijger Ronald R
Abstract excerpt
Adrenocortical carcinomas (ACCs) with sarcomatous areas represent an extremely rare type of highly aggressive malignancy of unknown molecular pathogenesis. The current study was planned to gain insight into its molecular genetics using a targeted next-generation sequencing approach and to explore the status of epithelial-mesenchymal transition (EMT)-associated markers (E-/P-/N-cadherins, MMP-2/-9 and caveolin-1),...
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