Article

Targeting oncogenic Wnt/β-catenin signaling in adrenocortical carcinoma disrupts ECM expression and impairs tumor growth

2022-10-24

Abstract excerpt

Adrenocortical carcinoma (ACC) is a rare, but highly aggressive cancer with limited treatment options and poor survival for patients with advanced disease. Improved understanding of transcriptional programs engaged in ACC will help direct rational, targeted therapies. While activating mutations in Wnt/β-catenin signaling are frequently observed, the β-catenin-dependent transcriptional targets that promote tumor pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 77e16b20-bde2-51af-8c98-d1289e124a93
DOI: 10.1101/2022.10.23.509323

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting oncogenic Wnt/β-catenin signaling in adrenocortical carcinoma disrupts ECM expression and impairs tumor growthDOI 10.1101/2022.10.23.509323Read

Therapeutic Targets for Adrenocortical Carcinoma in the Genomics EraSemantic proximity Read

Characterization of differential gene expression in adrenocortical tumors harboring beta-catenin (CTNNB1) mutations.Semantic proximity Read

Wnt/β-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in miceSemantic proximity Read

β-catenin activation is associated with specific clinical and pathologic characteristics and a poor outcome in adrenocortical carcinoma.Semantic proximity Read

Transcriptome analysis of adrenocortical cancers (ACC): from molecular classification to the identification of new treatmentsSemantic proximity Read

Expression of Wnt and TGF-β pathway components and key adrenal transcription factors in adrenocortical tumors: Association to carcinoma aggressivenessSemantic proximity Read

Aberrant activation of Wnt/β-Catenin signaling pathway drives the expression of poor prognosis-associated microRNAs in adrenocortical cancer with a major impact on miR-139-5p and its host gene PDE2ASemantic proximity Read

Comprehensive analysis of CTNNB1 in adrenocortical carcinomas: Identification of novel mutations and correlation to survivalSemantic proximity Read

Sarcomatoid adrenocortical carcinoma: a comprehensive pathological, immunohistochemical, and targeted next-generation sequencing analysis.Semantic proximity Read

Integrated genomic characterization of adrenocortical carcinoma.Semantic proximity Read

Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers.Semantic proximity Read

Aberrant expression of collagen type X in solid tumor stroma is associated with EMT, immunosuppressive and pro-metastatic pathways, bone marrow stromal cell signatures, and poor survival prognosisSemantic proximity Read