Article
Wnt/β-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors.
The Journal of clinical endocrinology and metabolism - 1 Feb 2011
Bonnet Stéphane, Gaujoux Sébastien, Launay Pierre, Baudry Camille, Chokri Ilham, Ragazzon Bruno, Libé Rossella, René-Corail Fernande, Audebourg Anne, Vacher-Lavenu Marie-Cécile, Groussin Lionel, Bertagna Xavier, Dousset Bertrand, Bertherat Jérôme, Tissier Frédérique
Abstract excerpt
BACKGROUND: Abnormal β-catenin immunohistochemistry and mutations of the β-catenin gene (CTNNB1) have been reported in adrenocortical adenomas (ACAs), but the frequencies of these defects and the phenotype of such tumors have not been clearly determined. OBJECTIVE: The objective of the study was...
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