Article
Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R.
PloS one - 1 Jan 2013
Gaujoux Sébastien, Hantel Constanze, Launay Pierre, Bonnet Stéphane, Perlemoine Karine, Lefèvre Lucile, Guillaud-Bataille Marine, Beuschlein Felix, Tissier Frédérique, Bertherat Jérôme, Rizk-Rabin Marthe, Ragazzon Bruno
Abstract excerpt
CONTEXT: Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the Wnt/β-catenin signaling pathway seems to play a major role in ACC aggressiveness, and might, thus, represent a promising therapeutic target. OBJECTIVE:...
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