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Article

Wnt/beta-catenin pathway deregulation in childhood adrenocortical tumors.

The Journal of clinical endocrinology and metabolism - 1 Oct 2011

Leal Letícia F, Mermejo Lívia M, Ramalho Leandra Z, Martinelli Carlos E, Yunes José A, Seidinger Ana Luiza, Mastellaro Maria José, Cardinalli Izilda A, Brandalise Silvia R, Moreira Ayrton C, Tone Luiz G, Scrideli Carlos A, Castro Margaret, Antonini Sonir R

Abstract excerpt

CONTEXT: CTNNB1/β-catenin mutations and activation of Wnt/β-catenin pathway are frequent in adult adrenocortical tumors (ACT), but data on childhood ACT are lacking. OBJECTIVE: The aim of the study was to investigate the presence of Wnt/β-catenin pathway abnormalities in childhood ACT. PATIENTS AND METHODS: Clinicopathological findings and outcome of 62 childhood ACT patients were analyzed regarding CTNNB1...

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Share to Adrenal Cortex Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21849527
DOI: 10.1210/jc.2011-0363

Genes

CTNNB1
SFRP1
AXIN1
DKK3
MYC
TCF7
WNT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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