Article
Mutations of beta-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors.
Cancer research - 1 Sept 2005
Tissier Frédérique, Cavard Catherine, Groussin Lionel, Perlemoine Karine, Fumey Gwladys, Hagneré Anne-Marie, René-Corail Fernande, Jullian Eric, Gicquel Christine, Bertagna Xavier, Vacher-Lavenu Marie-Cécile, Perret Christine, Bertherat Jérôme
Abstract excerpt
Adrenocortical cancer is a rare cancer with a very poor prognosis. The genetic alterations identified to date in adrenocortical tumors are limited. Activating mutations of the Wnt signaling pathway have been observed in more frequent cancers, particularly digestive tract tumors. We investigated whether Wnt pathway activation is involved in adrenocortical tumorigenesis. In a series of 39 adrenocortical tumors,...
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