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Article

Characterization of differential gene expression in adrenocortical tumors harboring beta-catenin (CTNNB1) mutations.

The Journal of clinical endocrinology and metabolism - 1 Jul 2011

Durand Julien, Lampron Antoine, Mazzuco Tania L, Chapman Audrey, Bourdeau Isabelle

Abstract excerpt

BACKGROUND: Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and adrenocortical carcinomas (ACC). However, the target genes of β-catenin have not yet been identified in adrenocortical tumors. OBJECTIVE: Our objective was to identify genes deregulated in adrenocortical tumors harboring CTNNB1 genetic alterations and nuclear accumulation of β-catenin. METHODS: Microarray analysis...

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Topics

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Share to Adrenal Cortex Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to beta Catenin

Share to Cell Line, Tumor

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Source

Identifiers

PMID: 21565795
DOI: 10.1210/jc.2010-2143

Genes

CTNNB1
RALBP1
ENC1
ISM1
PHYHIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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