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Article

A GA microsatellite in the Fli1 promoter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis.

Arthritis research & therapy - 1 Jan 2010

Morris Erin E, Amria May Y, Kistner-Griffin Emily, Svenson John L, Kamen Diane L, Gilkeson Gary S, Nowling Tamara K

Abstract excerpt

INTRODUCTION: The transcription factor Fli1 is implicated in the pathogenesis of systemic lupus erythematosus (SLE). Recently, a GA(n) polymorphic microsatellite was characterized in the mouse Fli1 promoter that modulates promoter activity and is truncated in two lupus mouse models compared to non-autoimmune prone mice. In this work, we characterize a homologous GA(n) microsatellite in the human Fli1 promoter....

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Identifiers

PMID: 21087477
DOI: 10.1186/ar3189
PMCID: PMC3046520

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