Article
A GA microsatellite in the Fli1 promoter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis.
Arthritis research & therapy - 1 Jan 2010
Morris Erin E, Amria May Y, Kistner-Griffin Emily, Svenson John L, Kamen Diane L, Gilkeson Gary S, Nowling Tamara K
Abstract excerpt
INTRODUCTION: The transcription factor Fli1 is implicated in the pathogenesis of systemic lupus erythematosus (SLE). Recently, a GA(n) polymorphic microsatellite was characterized in the mouse Fli1 promoter that modulates promoter activity and is truncated in two lupus mouse models compared to no...
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