Article
Acetylation impacts Fli-1-driven regulation of granulocyte colony stimulating factor.
European journal of immunology - 1 Oct 2016
Lennard Richard Mara L, Brandon Danielle, Lou Ning, Sato Shuzo, Caldwell Tomika, Nowling Tamara K, Gilkeson Gary, Zhang Xian K
Abstract excerpt
Fli-1 has emerged as a critical regulator of inflammatory mediators, including MCP-1, CCL5, and IL-6. The cytokine, granulocyte colony stimulating factor (G-CSF) regulates neutrophil precursor maturation and survival, and activates mature neutrophils. Previously, a significant decrease in neutrophil infiltration into the kidneys of Fli-1+/- lupus-prone mice was observed. In this study, a significant decrease in...
Topics
- Acetylation
- Animals
- Endothelial Cells
- Gene Expression Regulation
- Granulocyte Colony-Stimulating Factor
- Human Umbilical Vein Endothelial Cells
- Humans
- Inflammation
- Mice
- Mutation
- Neutrophils
- Promoter Regions, Genetic
- Protein Binding