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Article

Acetylation impacts Fli-1-driven regulation of granulocyte colony stimulating factor.

European journal of immunology - 1 Oct 2016

Lennard Richard Mara L, Brandon Danielle, Lou Ning, Sato Shuzo, Caldwell Tomika, Nowling Tamara K, Gilkeson Gary, Zhang Xian K

Abstract excerpt

Fli-1 has emerged as a critical regulator of inflammatory mediators, including MCP-1, CCL5, and IL-6. The cytokine, granulocyte colony stimulating factor (G-CSF) regulates neutrophil precursor maturation and survival, and activates mature neutrophils. Previously, a significant decrease in neutrophil infiltration into the kidneys of Fli-1+/- lupus-prone mice was observed. In this study, a significant decrease in...

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Source

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Identifiers

PMID: 27431361
DOI: 10.1002/eji.201646315
PMCID: PMC5175580

Genes

CCL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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