Article
The polymorphism of monocyte chemoattractant protein-1 is associated with the renal disease of SLE.
American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Dec 2002
Kim Hyun Lee, Lee Dong-Sup, Yang Seung Hee, Lim Chun Soo, Chung Jong Hoon, Kim Suhnggwon, Lee Jung Sang, Kim Yo Su
Abstract excerpt
BACKGROUND: Renal involvement in patients with systemic lupus erythematosus (SLE) varies from none to full-blown disease. Monocyte chemoattractant protein (MCP-1) is implicated in the activation of inflammatory cells and has been suggested to affect the progression of lupus nephritis (LN). METHODS: In the 5' flanking region of the MCP-1 gene, a guanine (G)/adenine (A) transition identified at position -2518...
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