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Article

Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2004

Zhang Xian K, Gallant Sarah, Molano Ivan, Moussa Omar M, Ruiz Phillip, Spyropoulos Demetri D, Watson Dennis K, Gilkeson Gary

Abstract excerpt

Increased Fli-1 mRNA is present in PBLs from systemic lupus erythematosus patients, and transgenic overexpression of Fli-1 in normal mice leads to a lupus-like disease. We report in this study that MRL/lpr mice, an animal model of systemic lupus erythematosus, have increased splenic expression of Fli-1 protein compared with BALB/c mice. Using mice with targeted gene disruption, we examined the effect of reduced...

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Identifiers

PMID: 15528390
DOI: 10.4049/jimmunol.173.10.6481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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