Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group.

PloS one - 1 Jan 2014

Monument Michael J, Johnson Kirsten M, McIlvaine Elizabeth, Abegglen Lisa, Watkins W Scott, Jorde Lynn B, Womer Richard B, Beeler Natalie, Monovich Laura, Lawlor Elizabeth R, Bridge Julia A, Schiffman Joshua D, Krailo Mark D, Randall R Lor, Lessnick Stephen L

Abstract excerpt

BACKGROUND: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood. EWS/FLI and related EWS/ETS chimeras upregulate numerous gene targets via promoter-based GGAA-microsatellite response elements. These microsatellites are highly polymorphic in humans, and preliminary evidence suggests EWS/FLI-mediated gene expression is highly dependent on the number of GGAA motifs within the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to DAX-1 Orphan Nuclear Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Nucleotide Motifs

Share to Oncogene Proteins, Fusion

Share to Proto-Oncogene Protein c-fli-1

Share to RNA-Binding Protein EWS

Share to Sarcoma, Ewing

Source

Open in PubMed Open full text

Identifiers

PMID: 25093581
DOI: 10.1371/journal.pone.0104378
PMCID: PMC4122435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group.PMID 25093581Read ↗

EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations.Semantic proximity Read ↗

Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's SarcomaSemantic proximity Read ↗

Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding.Semantic proximity Read ↗

Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.Semantic proximity Read ↗

Microsatellites are EWS/FLI response elements: genomic "junk" is EWS/FLI's treasure.Semantic proximity Read ↗

Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growthSemantic proximity Read ↗

Downstream EWS/FLI1 - upstream Ewing's sarcomaSemantic proximity Read ↗

The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcomaSemantic proximity Read ↗

Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility.Semantic proximity Read ↗

NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma.Semantic proximity Read ↗

GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome.Semantic proximity Read ↗

The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor geneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.