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Article

The Fli-1 Transcription Factor Regulates the Expression of CCL5/RANTES

7 Aug 2014

Abstract excerpt

The friend leukemia insertion site 1 (Fli-1) transcription factor, an Ets family member, is implicated in the pathogenesis of systemic lupus erythematosus in human patients and murine models of lupus. Lupus-prone mice with reduced Fli-1 expression have significantly less nephritis, prolonged survival, and decreased infiltrating inflammatory cells into the kidney. Inflammatory chemokines, including CCL5, are...

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PMID: 25098295
DOI: 10.4049/jimmunol.1302779

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