Association of functional (GA)n microsatellite polymorphism in the FLI1 gene with susceptibility to human systemic sclerosis.

doi:10.1093/rheumatology/keaa306

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Article

Association of functional (GA)n microsatellite polymorphism in the FLI1 gene with susceptibility to human systemic sclerosis.

Rheumatology (Oxford, England) - 1 Nov 2020

Yamashita Keita, Kawasaki Aya, Matsushita Takashi, Furukawa Hiroshi, Kondo Yuya, Okiyama Naoko, Nagaoka Shouhei, Shimada Kota, Sugii Shoji, Katayama Masao, Hirohata Shunsei, Okamoto Akira, Chiba Noriyuki, Suematsu Eiichi, Setoguchi Keigo, Migita Kiyoshi, Sumida Takayuki, Tohma Shigeto, Hamaguchi Yasuhito, Hasegawa Minoru, Sato Shinichi, Kawaguchi Yasushi, Takehara Kazuhiko, Tsuchiya Naoyuki

Abstract excerpt

OBJECTIVE: Susceptibility genes that can account for characteristic features of SSc such as fibrosis, vasculopathy and autoimmunity remain to be determined. In mice, deficiency of Friend leukaemia integration 1 transcription factor (Fli1) causes SSc-like disease with these features. The human FLI1 gene contains (GA)n microsatellite, which has been shown to be associated with expression level. Because...

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PMID: 32696043
DOI: 10.1093/rheumatology/keaa306

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