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Article

Microsatellites are EWS/FLI response elements: genomic "junk" is EWS/FLI's treasure.

Cell cycle (Georgetown, Tex.) - 1 Oct 2008

Gangwal Kunal, Lessnick Stephen L

Abstract excerpt

Ewing's sarcoma is a solid tumor of the bone that primarily occurs in children and young adults. Most cases harbor the (11;22) (q24;q12) chromosomal translocation that encodes the EWS/FLI oncoprotein. EWS/FLI is an aberrant ETS-type transcription factor that dysregulates a number of genes importa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Protein c-fli-1

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Source

Identifiers

PMID: 18927503
DOI: 10.4161/cc.7.20.6892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18927503-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Microsatellites are EWS/FLI response elements: genomic "junk" is EWS/FLI's treasure.PMID 18927503Read ↗

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The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcomaSemantic proximity Read ↗

EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations.Semantic proximity Read ↗

Downstream EWS/FLI1 - upstream Ewing's sarcomaSemantic proximity Read ↗

Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growthSemantic proximity Read ↗

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