Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Critical Role of the Transcription Factor Fli‐1 in Murine Lupus Development by Regulation of Interleukin‐6 Expression

22 Aug 2014

Abstract excerpt

OBJECTIVE: The Fli-1 transcription factor is implicated in the pathogenesis of systemic lupus erythematosus (SLE), both in humans and in animal models. Dysregulation of interleukin-6 (IL-6) is also associated with SLE. The purpose of this study was to investigate whether Fli-1 directly regulates the expression of IL-6. METHODS: Sera were collected from wild-type and Fli-1-heterozygous (Fli-1(+/-) ) MRL/lpr mice,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Inflammatory Myopathies and Dermatomyositis
Share to Rheumatoid Arthritis Research and Therapies
Share to Systemic Lupus Erythematosus Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25155007
DOI: 10.1002/art.38818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Critical Role of the Transcription Factor Fli‐1 in Murine Lupus Development by Regulation of Interleukin‐6 ExpressionPMID 25155007Read ↗

Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice.Semantic proximity Read ↗

Impact of Fli-1 transcription factor on autoantibody and lupus nephritis in NZM2410 miceSemantic proximity Read ↗

Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice.Semantic proximity Read ↗

Acetylation impacts Fli-1-driven regulation of granulocyte colony stimulating factor.Semantic proximity Read ↗

The Fli-1 Transcription Factor Regulates the Expression of CCL5/RANTESSemantic proximity Read ↗

IL-10 regulates murine lupus.Semantic proximity Read ↗

Fli-1 controls transcription from the MCP-1 gene promoter, which may provide a novel mechanism for chemokine and cytokine activation.Semantic proximity Read ↗

Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2.Semantic proximity Read ↗

Directing Transition from Innate to Acquired Immunity: Defining a Role for IL-6Semantic proximity Read ↗

Interleukin-6 induces expression of Ifi202, an interferon-inducible candidate gene for lupus susceptibility.Semantic proximity Read ↗

IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus.Semantic proximity Read ↗

Distinct roles of CSF-1 isoforms in lupus nephritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.